Desktop Software for Mac has just been updated to v220.127.116.11! With this update comes support to be able to synchronize your media files, backup and restore your data, and update software on BlackBerry PlayBook tablets running OS 2.1, PlayBook 4G and BlackBerry 10 Dev Alpha. Next time you fire up your DS for Mac, be sure to check for updates and get updated to this latest version. For more details on this release, see: BlackBerry Desktop Software - Manuals and Guides
Let us know any findings/fixes you may discover in the comments below!